Predicting Relapse After Cocaine Inpatient Cessation

Prospective Prediction of Cocaine Relapse After Inpatient Cessation by Combining Functional Imaging and Neuropsychological Biomarkers With Craving and Impulsivity Measures

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02416050

Acronym

QUIT-COC

Enrollment

Registered

2015-04-14

Start date

2015-02-03

Completion date

2022-01-03

Last updated

2023-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cocaine Dependence, Cocaine Use Disorder

Keywords

Cocaine, Dependence, Abstinence, Prediction, Model, Humans, MRI, Cognitive, Impulsivity, Craving

Brief summary

Can brain MRI at entry of cocaine inpatient cessation attempt predict relapse during a three month follow-up ? Hypothesis : White matter losses in the prefrontal cortex are associated with relapse to cocaine use.

Detailed description

A multivariate model using MRI parameters, craving score, impulsivity score, and neuropsychological testing results will be tested to predict relapse or continuous abstinence three month after cocaine inpatient cessation attempt.

Interventions

PROCEDUREBrain MRI imagery

Brain MRI performed during the first week of inpatient cocaine cessation

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* cocaine dependent patient requiring inpatient cessation * 18 years old and older * giving his/her consent to come back for visits up to three months * having a social insurance

Exclusion criteria

* minor * under guardianship * restraint hospitalization * contraindication to brain MRI * pregnant women

Design outcomes

Primary

Measure	Time frame
mean difference of fractional anisotropy of the prefrontal cortex (PFC) in patients abstinent from cocaine 3 months after inpatient detoxification compared to relapsers	at 3 months

Secondary

Measure	Time frame	Description
Comparisons between patients who remain abstinent from cocaine 3 months after inpatient detoxification and those who relapse	at baseline	Differences in grey and white matter volumes : voxel-based morphometry (VBM) and in resting-state whole-brain activity default mode network (DMN)
Among abstinent patients who remain abstinent at three months only :Differences between baseline and 3 months measures of Diffusion Tensor Imagery (DTI), VBM and DMN	at 3 months	—
Among abstinent patients who remain abstinent at three months only: Differences in scores of craving (visual scale and OCCS questionnaire) and impulsivity (UPPS)	at 3 months	—
Among abstinent patients who remain abstinent at three months only: Differences in performance at the stroop test and in mental flexibility during an implicit set shifting task compared to baseline results	at 3 months	—

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026