Mental Disorders, Mental Disorders Diagnosed in Childhood, Psychiatric, Diagnosis, Psychological Disorders
Conditions
Keywords
children, mental health, family genetic study
Brief summary
The purpose of this research is to study new ways of classifying mental disorders in children based on observable behavior and genetics to ultimately diagnose these disorders better.
Detailed description
The NIMH Research Domain Criteria (RDoC) initiative seeks to further a long-range goal of contributing to diagnostic systems as informed by research on genetics, neuroscience, and behavior. The RDoC approach is based on identifying the most elemental units of analysis relevant to psychiatric disorders (such as genes and molecules) and using this matrix as a framework for investigation. In this case-control family study, the investigators will be using self-report questionnaires and computer-based tests to develop diagnostic methods for neuropsychiatric disorders in children, their siblings, and their parents. They will do this by recruiting normal and affected children, their siblings, and their parents. They will look at the subject, sibling, and parents to determine if psychiatric disorders are inherited. Affected children, ages 6-12, are those who have been diagnosed with a psychiatric disorder. Participants will undergo a battery of questionnaires/evaluations and a blood draw. The investigators will determine if the questionnaires and tests that reflect the constructs (such as reward prediction and willingness to work) predict psychopathology and impairment. The blood draw will be genotyped to determine if the measured constructs are associated with neuropsychiatric candidate genes, cross-disorder candidate gens and a cross-disorder polygenic score.
Interventions
None listed
Sponsors
National Institute of Mental Health (NIMH)
State University of New York - Upstate Medical University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
6 Years to 12 Years
Healthy volunteers
Yes
Inclusion criteria
* male or female, ages 6-12. * biological child of parent(s) participating in testing.
Exclusion criteria
* taking psychotropic medications. * free of uncontrolled medical problems. * major sensorimotor disability (e.g., deafness, blindness). * diagnosed neurological condition. * inadequate command of the English language. * history of head injury with loss of consciousness lasting longer than 10 minutes. * IQ estimated at below 80.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reward Valuation | Baseline | Measures: Self-report, computerized tests, and DNA samples; Assessing correlations among family members and predictors of psychopathology. |
| Effort Valuation/Willingness to Work | Baseline | Measures: Self-report, computerized tests, and DNA samples; Assessing correlations among family members and predictors of psychopathology. |
| Expectancy/Reward Prediction Error | Baseline | Measures: Self-report, computerized tests, and DNA samples; Assessing correlations among family members and predictors of psychopathology. |
| Initial Responsiveness to Reward Attainment | Baseline | Measures: Self-report, computerized tests, and DNA samples; Assessing correlations among family members and predictors of psychopathology. |
Countries
United States
Outcome results
None listed