The Effect of Humor and Laughter on C Reactive Protein: A Pilot Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02415231

Enrollment

Registered

2015-04-14

Start date

2015-04-30

Completion date

2016-08-31

Last updated

2017-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

humor laughter C reactive protein

Brief summary

The study is to see if watching humor and laughing can affect CRP levels in healthy individuals. This is a randomized controlled trial.

Detailed description

Subjects will be…males and females: students, employees, and members of the community. 5\. Subjects will be between \_\_\_18\_ and \_\_\_99\_ years of age. 6\. In total, subject participation will last approximately \_\_\_1 day for 90 minutes\_ 7\. Subjects will be recruited \_by word of mouth at the Loma Linda University Campus and surrounding communities\_\_\_. 8\. Consent will take place \_by investigators in Nichol Hall Room A620/A640\_\_\_. 9\. If Multi-center: 10\. If Single center or investigator-initiated: \_60\_\_ subjects will participate in the study.

Interventions

BEHAVIORALhumor

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 99 Years

Healthy volunteers

Yes

Inclusion criteria

* Ages 18-99 yrs , healthy individuals

Exclusion criteria

* Under 18 years old, or over 99 years old, non healthy individuals

Design outcomes

Primary

Measure	Time frame
CRP level	change in CRP levels over 3 time frames (baseine, immediately after intervention, and 30 minutes later)

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026