Pain, Stress
Conditions
Keywords
Pain and stress assessment in premature infants
Brief summary
The study will measure the effects of eye exams on markers of stress in the urine. In addition, measurements will be taken to show the effects of stress on brain activity, O2 sats, and blood flow.
Interventions
None listed
Sponsors
Loma Linda University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
24 Weeks to 32 Weeks
Healthy volunteers
Yes
Inclusion criteria
* Premature infants between 24 -32 weeks of gestational age
Exclusion criteria
* Infants scheduled for laser eye surgery on the day of the examination * Infants with intraventricular hemorrhage ≥ grade 3 (Papile classification) diagnosed by head ultrasound * Infants receiving the following medications: morphine, fentanyl, methadone, midazolam, lorazepam, muscle relaxants, phenobarbital, phenytoin, levetiracetam * Renal injury defined with plasma creatinine \> 1.5 mg/dL * Severe cyanotic congenital heart disease * Unstable respiratory distress (hypoxemia PaO2 \< 50 mm Hg or SpO2 \< 90%)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Urine Stress Marker | 24 hours | Collection to occur 3-4 hours before eye exam and 24 hours after the eye exam. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| aEEG | 24 hours | 1 hour prior to the eye examination and will remain there until 24 hours after the end of the eye exam. |
| NIRS | 24 hours | 1 hour prior to the eye exam and will be kept in place until 24 hours after the end of the eye exam |
Countries
United States
Outcome results
None listed