Goal Directed Therapy for Acute Kidney Injury in Critical Ill Patients

Goal Directed Therapy in the Early Phase of Acute Kidney Injury in Critical Ill Patients

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02414906

Acronym

GDT-AKIN

Enrollment

Registered

2015-04-13

Start date

2010-06-30

Completion date

2014-12-31

Last updated

2015-04-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury

Keywords

Goal Directed Therapy, Acute Kidney Injury

Brief summary

Acute kidney injury (AKI) is a frequent complication in critically ill patients admitted to intensive care unit (ICU) and it is associated with increased morbimortality. There is evidence that perioperative hemodynamic optimization decreases the incidence of AKI in the post operative phase in high-risk patients. We aimed to evaluate if the use of a goal-directed therapy to increase oxygen delivery in the early phase of acute kidney injury can decrease the prevalence of patients with acute renal failure.

Detailed description

Randomized, controlled, multicenter study.The intervention group was monitored with Flo Trac/Vigileo and optimized with fluid challenges, dobutamine and blood transfusion, if necessary, to maintain a IDO² ≥600ml/min/m² during 8h. The control group was treated according to the discretion of the attending physician.

Interventions

OTHERGoal-directed therapy

Goal-directed therapy with fluids and dobutamine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients admitted in the Intensive Care Unit with Acute Kidney Injury (AKI) classified as AKIN 1 (increase in serum creatinine ≥0.3 mg/dL and/or urine output less than 0.5 ml/kg/h over 6 hours) for less than 12 hours.

Exclusion criteria

* ICU length of stay \>10 days, nefrectomy, chronic kidney disease undergoing hemodialysis, baseline creatinine ≥4 mg/dL, life expectance ≤ than 1 month, pregnancy, severe arrhythmia, severe heart failure (≤ III, NYHA), acute myocardial infarction (AMI)

Design outcomes

Primary

Measure	Time frame
acute kidney injury	2 months

Secondary

Measure	Time frame
death	2 months

Other

Measure	Time frame
lenght of stay	2 months

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 5, 2026