Re-Epithelialization, Wound
Conditions
Keywords
Phenytoin, Skin graft donor site, Clean surgical site, Wound model
Brief summary
The purpose of this study is to investigate the potential healing properties of phenytoin. The investigators will use the donor site of a split skin thickness graft (SSTG) to model a basic wound in a randomized controlled trial of topical phenytoin against current best clinical practice. The investigators aim to demonstrate a dose dependent effect. The investigators hypothesis, based on previous clinical experience at our center and on current available literature, that phenytoin will reduce wound healing time.
Interventions
DRUGPhenytoin
Topical use of phenytoin solution on dressings of split thickness skin graft sites.
DRUGSugar solution
Sponsors
Children's Surgical Center, Cambodia
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
No minimum to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Undergoing split thickness skin graft during trial time period at Children's Surgical Centre
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage rate of re-epithelialization | Participants will be followed for the duration of hospital stay, an expected average of 20 days | Pictures taken of wound site every other day will be analysed using imaging software for size of wound. Percentage rate will be calculated from this. |
| Appearance of infection | Participants will be followed for the duration of hospital stay, an expected average of 20 days | Pictures taken of wound site every other day will be analysed using imaging software and the Southampton wound grading scale |
Countries
Cambodia
Contacts
Primary ContactJim Gollogly
Outcome results
None listed