Liver Neoplasms
Conditions
Keywords
contrast-enhanced ultrasound, biopsy
Brief summary
The purpose of this study is to estimate the clinical value of contrast-enhanced ultrasound in percutaneous biopsy for liver occupied lesion.
Detailed description
The patients with liver neoplasms who need receive percutaneous biopsy were randomized into contrast-enhanced ultrasound(CEUS) group and conventional ultrasound(US) group.The aims include: 1. Comparison the diagnostic accuracy rate, specificity and sensitivity between CEUS and US group. 2. Comparison the diagnostic accuracy rate specificity and sensitivity between smaller(\<3cm) and larger(≥3cm) nodule group. 3. To explore operating strategy of contrast-enhanced ultrasound guided biopsy. 4. To evaluate economic efficiency of contrast-enhanced ultrasound guided biopsy compared with conventional ultrasound guided biopsy.
Interventions
OTHERCEUS guided biopsy
Biopsy was operated under contrast-enhanced ultrasound-guided.
OTHERUS guided biopsy
Biopsy was operated under conventional ultrasound-guided.
DEVICEUltrasound
Sponsors
Peking University Cancer Hospital & Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients with liver occupied lesion who cannot be diagnosed by imaging examination or need pathological results
Exclusion criteria
* severe anemia * PLT\<60000/mm3,prothrombin activityprothrombin time activity\<70% * women during menstruation, pregnancy, child birth and baby nursing period * patients with severe mental disorder * cardiopulmonary failure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| diagnostic accuracy | 12 months | diagnostic accuracy=（true positive+ ture negative)/number of parcitipants |
Countries
China
Contacts
Primary ContactKun Yan, master
Backup ContactWei Wu, doctor
Outcome results
None listed