Effects of Replacing Diet Beverages With Water on Weight Loss and Plasma Glucose Control in Type 2 Diabetes

Effects of Replacing Diet Beverages With Water on Type 2 Diabetic Obese Females Attending a Weight Loss Program - a Randomized, 24 Week Clinical Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02412774

Enrollment

Registered

2015-04-09

Start date

2015-04-30

Completion date

2016-01-31

Last updated

2019-10-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obese, Overweight, Type 2 Diabetes

Keywords

diet beverages, water, diabetes, weight loss, insulin sensitivity

Brief summary

The purpose of the present study is to evaluate the effect of replacing diet beverages with water on weight loss and biochemical indicators for insulin sensitivity and cardiometabolic risk factors of diabetic obese and overweight female adults when they are in a multidisciplinary weight loss plan.

Interventions

BEHAVIORALDBs at the end of the main meal + Diet

Subjects are asked to have 250 ml DBs at the end of their lunch as the main meal, while they are on a multidisciplinary diet plan for 24 weeks.

BEHAVIORALWater at the end of the main meal+ Diet

Subjects are asked to have 250 ml water at the end of their lunch as the main meal, while they are on a multidisciplinary diet plan for 24 weeks.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

* Diabetic female patient with 6.5\<H1AC\<7.2. * Monotherapy with Metformin. * 18-45 years of age. * Body mass index (BMI) between 27-35 kg/ m². * Consume DBs regularly during their habitual diet. * Must be able to have moderate exercise. * Must be interested to have weight loss.

Exclusion criteria

* Participating in a research project involving weight loss or physical activity in the previous six months. * Pregnancy or lactation during the previous 6 months, or planned pregnancy in the next six months. * Taking medication that could affect metabolism or change body weight. * Report heart problems, chest pain, and cancer within the last five years. * Unwilling to change intake of beverages during the study period.

Design outcomes

Primary

Measure	Time frame
Weight loss	24 weeks

Secondary

Measure	Time frame
Insulin resistance (HOMA)	24 weeks
Lipid profiles	24 weeks
Fasting plasma glucose	24 weeks
BMI	24 Weeks
HA1C	24 Weeks
Waist circumference	24 weeks

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026