Effects of Chest Physiotherapy (CPT) on Lung Clearance Index (LCI) in Non Cystic Fibrosis (CF) Bronchiectasis

Short-term Effects of Chest Physiotherapy on Ventilation Inhomogeneity in Non-CF Bronchiectasis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02411981

Enrollment

Registered

2015-04-08

Start date

2015-04-30

Completion date

2016-02-29

Last updated

2016-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchiectasis

Keywords

Lung Clearance Index, Non cystic fibrosis Bronchiectasis, Multiple Breath Nitrogen Washout

Brief summary

This study will investigate the effects of on technique of chest physiotherapy on pulmonary function. Effects of pulmonary function will be measured by the spirometry, body plethysmography and by the multiple breath nitrogen washout technique.

Detailed description

This is a before-after intervention study. Spirometry, body plethysmography and then multiple breath nitrogen washout will be measured before the application of chest physiotherapy. The chest physiotherapy technique used will be autogenic drainage during 30 minutes. A resting period of 5 minutes will be given to the participant before the following tests. Spirometry, body plethysmography and then multiple breath nitrogen washout will be measured again, in the same order, after the application of chest physiotherapy.

Interventions

OTHERAutogenic drainage

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Non cystic fibrosis bronchiectasis in stable state

Exclusion criteria

* Not in stable state * Bronchiectasis with severe respiratory morbidities likely to reduce the chest physiotherapy session efficacy (e.g. : severe chronic obstructive pulmonary disease)

Design outcomes

Primary

Measure	Time frame	Description
Change of Lung Clearance Index (LCI)	up to 80 minutes	LCI will me measured before and after the chest physiotherapy session

Secondary

Measure	Time frame	Description
Change of Spirometry	up to 40 minutes	Forced expired volume in one second (FEV1) and Forced expired flow at 25-75% of the forced vital capacity (FEF25-75) will be measured before and after the chest physiotherapy session
Sputum weight	35 minutes	Sputum will be collected during the 30 minutes of chest physiotherapy session and 5 minutes immediately after. Sputum weight will be measured and correlated with change of LCI and spirometry values

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 27, 2026