Optimal Low B-value in Intravoxel Incoherent Motion Diffusion-weighted MR Imaging of the Brain

Can the Distribution of Low B-value and the NEX Influence the Pseudodiffusion Parameter Derived From IVIM in Brain?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02411864

Enrollment

Registered

2015-04-08

Start date

2014-11-30

Completion date

2014-12-31

Last updated

2017-07-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Volunteers

Keywords

IVIM, brain, diffusion-weighted imaging

Brief summary

Our research aims to reveal whether the low b-values distribution and the number of NEX for each b value will influence the accuracy of pseudodiffusion parameter derived from IVIM in brain.

Detailed description

As an improved MRI technique, diffusion-weighted imaging (DWI) is considered the most sensitive for early pathological changes. Perfusion measurement has been shown to improve sensitivity and predictive value for tumor grading and prognosis, also as a predicator of recovery with reperfusion in patients of acute ischemic stroke.Our research aims to reveal whether the low b-values distribution and the number of NEX for each b value will influence the accuracy of pseudodiffusion parameter derived from IVIM in brain.

Interventions

OTHERdifferent low b-values distribution

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Age

25 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* no hypertension or cerebral vascular diseases, * no systemic metabolic disease; * no infection or fever; * no use of corticosteroid drugs; * no MRI contraindication.

Design outcomes

Primary

Measure	Time frame
Parameters D* and f in healthy white matter or gray mater	2-3 days

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026