Gonarthrosis
Conditions
Keywords
Deep venous thromboembolism, Femoral nerve block, Total knee arthroplasty
Brief summary
To investigate whether preemptive analgesic of femoral nerve block could prevent deep venous thromboembolism due to inhibiting the excessive release of neutrophil elastase and inflammatory cytokines.
Detailed description
Femoral nerve block is an effective analgesic mode in patients after total knee arthroplasty. In recent studies, there has been shown that a large amount of neutrophil elastase release from neutrophils could induce the development of deep venous thromboembolism and femoral nerve block may reduce the incidence of the development of deep venous thromboembolism. In addition, inflammatory cytokines including interleukin-1(IL-1), IL-6, IL-8 and tumor necrosis factor(TNF) were associated with deep venous thromboembolism. Thus, the investigators hypothesised that preemptive analgesic of femoral nerve block could prevent deep venous thromboembolism due to inhibiting the excessive release of neutrophil elastase and inflammatory cytokines.
Interventions
PROCEDUREfemoral nerve block
use the nerve stimulator,the femoral nerve block will be administered before or after the surgery
Sponsors
General Hospital of Ningxia Medical University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* adult patients scheduled for total knee arthroplasty under general anesthesia
Exclusion criteria
* ASA physical status Ⅳ-Ⅴ, * psychiatric illness, * chronic opioid consumption, * patient refusal, * coagulopathy, * peripheral neurological injury, * local anesthesia drug allergy, * preoperative existing deep venous thromboembolism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum concentration of inflammatory cytokine | change from baseline at 30min, 60min, 90min after using tourniquet and 12h, 24h,48h after operation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of related inflammatory factors of deep venous thromboembolism | change from baseline at 30min, 60min, 90min after using tourniquet and 12h, 24h,48h after operation | inflammatory factors include IL-1, IL-6, IL-8 and TNF，detecting the concentrations by enzyme-linked immunosorbent assay (ELISA). |
Other
| Measure | Time frame | Description |
|---|---|---|
| Diagnosis of deep venous thromboembolism by ultrasonography | 2day and 7day after operation | result of diagnosis is yes or no |
Countries
China
Contacts
Primary ContactXinli Ni
Outcome results
None listed