Collagen Fibril Alteration
Conditions
Brief summary
The researchers will assess the effects of treatment with tretinoin cream on human skin by using non-invasive optical imaging technologies.
Detailed description
The researchers will evaluate changes in the dermis and skin properties as the effect of treatment with Tretinoin cream (0.1%) by using the following optical imaging techniques. 1. Multiphoton microscopy using a clinical tomograph (MPTflex, Jenlab, Germany) 2. Multispectral Imaging using a device developed at Beckman Laser Institute, UC Irvine
Interventions
Assessment of the skin change
Sponsors
Unilever R&D
Beckman Laser Institute University of California Irvine
University of California, Irvine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
45 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Female 45 years of age or older - Skin type scale I to III
Exclusion criteria
* Large amount of dark, coarse hair on the arms * History of allergies to alpha hydroxy acids (AHAs), retinoids, soaps, fragrances, sunscreens or Latex * Currently using over-the-counter AHA or retinol within one month or prescription retinoid within three months of the start of the study. * History of skin cancer, including squamous or basal cell carcinoma at the treatment site or history of malignant melanoma. * History of diabetes * Currently pregnant or nursing
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Skin Collagen/Elastin ratio over time - Change from baseline in sun exposed, and non sun exposed skin areas. | up to 2 months | The effects of tretinoin cream on human skin will be measured. |
Countries
United States
Outcome results
None listed