Infertility
Conditions
Keywords
endometrial scratch, IVF, randomized controlled study, Prospective controlled trial, Different time to perform endometrial scratch, In vitro fertilization, embryo transfer
Brief summary
Many studies have demonstrated that endometrial scratch significantly increase pregnancy rate in patients undergoing in vitro fertilization and embryo transfer. However, only a limited number of studies have been conducted in frozen thawed transfer (FET) cycle. Nowadays, in FET cycles, endometrial scratch is mainly performed on two different time points: 1) luteal phase in the previous cycle; 2)early follicular phase in the current cycle. However, few studies have compared the effectiveness of those two different endometrial scratch methods performed in different timing. The aim of this study is to find the best timing of endometrial scratch in FET cycles.
Interventions
PROCEDUREendometrial scratch
local injury to the endometrium by Pipelle
Sponsors
The First Affiliated Hospital of Zhengzhou University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* To be aged younger than 40 years old; * At least one period IVF-ET (fresh or thaw) has been done and not pregnant after at least one qualified blastocyst (more than 3BB) or two qualified embryos (more than II/6) have been transferred; * There are qualified embryos thawed and the thaw-ET period will be taken.
Exclusion criteria
* Malformation of uterus: such as uterus uni-corns, uterus bi-corns, untreated uterus septus, etc.; * History of endometrial diseases: such as intrauterine adhesion, uterine cavity tuberculosis, severe dysplasia of endometrium, etc.; * Multiple myomata or endometrioma which causes uterus oppression; * Multiple and recurrent endometrial polyps; * Pelvic tuberculosis, endometriosis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical pregnancy rate | 35 days after embryo transfer | See heart beat with ultrasonic exam. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Ectopic pregnancy rate | 35 days after embryo transfer | No sac can be seen inside uterine 35 days after embryo transfer, but with high hCG level |
Countries
China
Contacts
Primary ContactYingpu Sun, MD,PhD
Backup ContactLinli Hu, MD,PhD
Outcome results
None listed