Infertility
Conditions
Brief summary
The role of hysteroscopy in infertility investigation is to detect possible intrauterine changes that could interfere with implantation or growth or both of the conceptus, with the invention of miniature hysteroscope, it is possible to perform hysteroscopy in an office setting (Outpatient hysteroscopy; OH), for diagnostic and certain therapeutic intervention. It is currently acknowledged as the 'gold standard' investigation of the intrauterine abnormalities. Cervical priming prior to diagnostic hysteroscopy softens the cervix and lessens the force needed for dilation, thereby potentially reducing the probability of procedural complication such as uterine perforation, cervical laceration, failure to dilate, and creation of a false track that can occur during cervical entry. Misoprostol is a prostaglandin El analogue, that can be administered either orally or vaginally, that can cause cervical ripening by inducing collagenolytic activity and synthesis of proteoglycans.
Interventions
DRUGMisoprostol , Prostaglandins E1 analogue
Sponsors
Kasr El Aini Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Female patients aged from 20 to 40 years old. * They are complaining with primary or secondary infertility. * They undergo investigations including husband semen analysis, hormonal assay, U/S, Hystrosalpingography.
Exclusion criteria
* Known sensitivity to misoprostol. * Any systemic disease contraindicating the use of prostaglandins (cardiovascular disease, hypertension, renal failure, etc). * Concomitant neurologic disease that could affect the correct evaluation of pain. * Pregnancy. * Any contraindication to hysteroscopy such as Pelvic inflammatory disease (PID). * Heavy uterine bleeding. * Any uterine abnormality such as pinhole cervix that would obviate passage of a catheter through the cervix.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| level of pelvic pain according to a 10-point visual analogue scale (VAS) | 10 months | The level of pelvic pain will be rated according to a 10-point visual analogue scale (VAS). The VAS will be applied immediately after the procedure ended |
Countries
Egypt
Contacts
Primary ContactYomna A Bayoumi, MD
Outcome results
None listed