Low-grade Serous Ovarian Carcinoma, Recurrent Invasive Borderline Serous Ovarian Cancer
Conditions
Keywords
chemotherapy, hormone therapy, borderline, low-grade, serous ovarian cancer
Brief summary
The purpose of this study is to retrospectively evaluate treatments and outcomes of patients with low grade serous ovarian carcinomas in Italy.
Interventions
None listed
Sponsors
National Cancer Institute, Naples
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosis low-grade serous ovarian carcinoma * OR invasive recurrence after surgical resection of borderline serous ovarian carcinoma * Availability of archival tumor specimen (paraffin embedded block) for central analysis and evaluation for mutations * Age \> 18 years * Signed informed consent
Exclusion criteria
* High-grade serous, mucinous, endometrioid, or any other non-low-grade serous ovarian carcinoma * Unavailability of archival tumor specimen
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| number of patients with objective tumor response after receiving combination hormonal and chemotherapy | 6 months |
| risk of recurrence in patients with low-grade serous ovarian carcinoma | two years |
| number of patients with objective tumor response after receiving chemotherapy | 6 months |
| number of patients with objective tumor response after receiving hormone therapy | 6 months |
| progression free survival | 2 years |
| overall survival | 5 years |
Countries
Italy
Contacts
Primary ContactFrancesco Perrone, MD PhD
Backup ContactTeresa Ribecco, PhD
Outcome results
None listed