A Retrospective Study on Drug Induced Liver Injury in China

Conditions

Drug-Induced Liver Injury

Keywords

Drug-Induced Liver Injury, DILI

Brief summary

This is a multi-center, open-enrollment, retrospective, non-interventional epidemiologic study without any clinical treatment. Its primary objective is to understand 1) incidence of drug-induced liver injury, including incidences among all the hospitalized patient, among patients in department of hepatic diseases, digestive diseases, oncology, hematology etc., individually; 2) epidemiologic characteristics of drug-induced liver injury, including suspected medications, clinical types, histological characteristics, severity and outcomes.

Detailed description

This is a multi-center, open-enrollment, retrospective, non-interventional epidemiologic study without any clinical treatment. Its primary objective is to understand 1) incidence of drug-induced liver injury, including incidences among all the hospitalized patient, among patients in department of hepatic diseases, digestive diseases, oncology, hematology etc., individually; 2) epidemiologic characteristics of drug-induced liver injury, including suspected medications, clinical types, histological characteristics, severity and outcomes. It investigates medical records of patients who were hospitalized during 2012 to 2014. Those patients should be diagnosed as drug-induced liver injury, drug-induced liver disease, drug-induced hepatitis, drug-induced hepatocirrhosis, drug-induced hepatic failure, or any other similar diagnosis of drug-induced liver injury nature.

Jing Li, Jianzhong Zhang, Xiaorong Xu, Weidong Fang, Shilin Qu et al. (11 authors)

Expert Review of Clinical Pharmacology2021-09-157 citations

10.1080/17512433.2021.1981859

Interventions

None listed

Study design

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

No

Inclusion criteria

* Any hospitalized patients who were diagnosed as drug-induced liver injury, drug-induced liver disease, drug-induced hepatitis, drug-induced hepatocirrhosis, drug-induced hepatic failure, or any other similar diagnosis of drug-induced liver injury nature. * The drug-induced liver injury and similar diagnosis were not excluded the possibility of drug-induced nature.

Exclusion criteria

* Confirmed non-drug induced liver injury. * Insufficient clinical data supporting the diagnosis of drug-induced liver injury. * Liver injury resulted from poisons and chemicals.

Design outcomes

Primary

Measure	Time frame
diagnosis of drug-induced liver injury	6 months

Countries

China

Outcome results