Normal Values for Esophageal High Resolution Manometry in an Advanced Protocol Including Liquid Swallows and a Solid Test Meal

Normal Values for Esophageal High Resolution Manometry in an Advanced Protocol Using a Test Meal

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02407938

Acronym

Rice

Enrollment

Registered

2015-04-03

Start date

2014-01-31

Completion date

2015-06-30

Last updated

2015-12-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

dysphagia, reflux symptoms, retrosternal pain

Brief summary

Normal values for measurements of high resolution manometry in a protocol which includes isolated liquid swallows in upright and recumbent position, free drinking of water, a solid test meal and a postprandial observational period will be determined.

Detailed description

The investigators will recruit healthy volunteers and ask for study participation. After providing informed consent, participants will be questioned using standardized questionnaires assessing symptoms of reflux, dysphagia, gastrointestinal symptom burden and depression. Participants will be tested using our advanced protocol for high resolution esophageal manometry. This protocol includes individual liquid swallows, free drinking of water, a standardized test meal (200g rice) and a postprandial observational period. Normal values for liquid and solid swallows will be determined.

Interventions

OTHERRice meal

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Healthy volunteers without gastrointestinal co-morbidity

Exclusion criteria

* Inability or unwillingness to provide informed consent * Any relevant current or past gastrointestinal morbidity (including diseases relevant previous surgery). * Relevant gastrointestinal symptoms * Relevant medication (as specified below) within the last 4 weeks * Age below 18 years

Design outcomes

Primary

Measure	Time frame	Description
Values for HRM data (IRP, DCI, DL) in healthy volunteers	1 hour	Normal values for measurements of high resolution manometry in a protocol which includes isolated liquid swallows in upright and recumbent position, free drinking of water, a solid test meal

Secondary

Measure	Time frame	Description
discomfort on a VAS from 1-10 for each type of measurement	1 hour	Discomfort during different steps of the investigation

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 9, 2026