Cannabis, Psychotic Disorders
Conditions
Brief summary
The overarching goal of this study is to characterize the effects of cannabinoids on working and episodic memory.
Detailed description
This study will be achieved by studying the acute effects of delta-9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis and a cannabinoid-1 receptor (CB1R) agonist, on a wide range of memory tasks in healthy human subjects.
Interventions
DRUGTHC
Active THC (0.0015-0.03 mg/kg) administered over 20 minutes.
DRUGPlacebo
Control: small amount of alcohol intravenously (quarter teaspoon), with no THC over 20 minutes.
Sponsors
Yale University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Men and women aged 18 and 55 years (extremes included) on day of first dosing * Exposed to cannabis at least once in their lifetime
Exclusion criteria
* Cannabis naive * Positive pregnancy screen during screening * Hearing deficits
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rey Auditory Verbal Learning Test (RAVLT) | +35 minutes after infusion | a measure of verbal episodic memory |
| N-Back Task | +65 minutes after infusion | a measure of working memory |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinician Administered Dissociative Symptoms Scale (Total Score) | Baseline, +10, +85, and +240 minutes after the first infusion | — |
| Visual Analog Scale (Total Score) | Baseline, +10, +85, +240 minutes after the first infusion | a measure of THC intoxication |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORMohini Ranganathan, M.D.
Assistant Professor
Outcome results
None listed