Pain, Postoperative
Conditions
Keywords
postoperative pain, surgery, pain resolution, pain intensity, persistent postsurgical pain, pain-related genes, analgesic
Brief summary
The purpose of this research study is to determine what causes pain after surgery to increase or decrease over time.
Detailed description
Before surgery, study participants will be asked questions about age, gender, race/ethnicity, annual income, and education level. Study participants will also be questioned regarding prior pain experiences, their mood and how they think about pain. A small test tube of blood, a cheek swab or a saliva sample will be taken to see what genetic differences may influence individuals pain after surgery. After surgery, study participants will be asked questions about their pain intensity while in the hospital. Additional information will be collected about the effects of pain medicine, and their recovery from surgery. Following discharge from the hospital, study participants will be contacted monthly to confirm continued communication. Study participants will also be contacted six months after surgery, and asked to complete a final survey about their pain after surgery.
Interventions
BEHAVIORALSurgical patients' clinical progression
Study the dynamic nature of pain
GENETICGenetic markers
Research variants in genes related to pain sensitivity, analgesic sensitivity and opioid response
Sponsors
National Institute of General Medical Sciences (NIGMS)
University of Florida
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 18 years of age or older * anticipated length of hospital stay of 72 hours or greater * expected post-operative survival greater than 6 months
Exclusion criteria
* \< 18 years of age * anticipated need for prolonged post-operative intubation (greater than 24 hours) * urgent or emergent surgical procedure * inability to understand or participate in questionnaires, surveys or data collection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measure postoperative pain scores change with respect to time | up to 7 days | Pain scores will be measured using previously established pain scale and Questionnaire |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measure variables that contribute to postoperative pain scores | up to 6 months | Variables: clinical, biological, psychological, and social factors |
| Measure timing patterns that may influence development of persistent postsurgical pain (PPP) | up to 6 months | Different patterns of pain analgesia-pain cycles |
| Genetic testing | up to 1 day | Specific single nucleotide polymorphisms |
Countries
United States
Outcome results
None listed