Birth Rate, Embryo Implantation, Reproductive Techniques, Thrombophilia
Conditions
Brief summary
Both hereditary and acquired thrombophilia have been associated with recurrent miscarriage and pregnancy complications. Thrombophilia could favor the development of thrombosis of the maternal vasculature and obstacle placentation. Some studies have suggested a role of thrombophilia in the failure of assisted reproductive techniques although this association has been recently questioned. The scope of this study is to evaluate the effect of thrombophilia on the implantation rate and live birth rate in women undergoing ART. Design: prospective, observational study Primary end-point: live birth rate. Secondary end-points: implantation rate, venous thromboembolic events during ART up to 6 weeks post-partum
Interventions
None listed
Sponsors
G. d'Annunzio University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* women undergoing ART * age 18 years or older
Exclusion criteria
* ongoing anticoagulant therapy * previous venous thromboembolism * no informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth rate | Participants will be followed for the duration of the pregnancy, an expected average of 9 months |
Secondary
| Measure | Time frame |
|---|---|
| implantation rate | Participants will be followed from the implantation to the ultrasonography to document the gestational sac, an expected average of 7 weeks |
Countries
Italy
Outcome results
None listed