Major Depression in Remission
Conditions
Brief summary
The purpose of this study is to explore the effectiveness of an internet-delivered cognitive control training as a preventive intervention for remitted depressed patients.
Detailed description
Prospective studies have linked impaired cognitive control to increased cognitive vulnerability for future depression. Importantly, experimental studies indicate that cognitive control training can be used to reduce rumination and depressive symptomatology in MDD samples. Furthermore, studies exploring the potential of cognitive control training in at-risk undergraduate students indicate that cognitive control training has beneficial effects on rumination, an important vulnerability factor for depression. Provided that remitted depressed patients form a high-risk group for developing future depressive episodes, the current study will explore whether internet-delivered cognitive control training can be used to reduce vulnerability for future depression in remitted depressed patients. The investigators will explore effects on depressive symptomatology, (mal-)adaptive emotion regulation (directly following training and at 3 months follow-up), and indices of functioning (at 3 months follow-up).
Interventions
BEHAVIORALCognitive Control Training
10 adaptive Paced Auditory Serial Addition Task (PASAT) sessions, 400 trials each
BEHAVIORALLow Cognitive Load Training
10 low cognitive load sessions, 400 trials each
Sponsors
University Ghent
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
23 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* History of ≥ 1 depressive episode(s) * Currently in stable full or partial remission (≥ 6 months)
Exclusion criteria
* Major depressive disorder (MDD; current) * Bipolar disorder (current and/or previous) * Psychotic disorder (current and/or previous) * Neurological impairments (current and/or previous) * Excessive substance abuse (current and/or previous) * No other comorbid disorders (current) * No ongoing psychotherapeutic treatment (maintenance treatment is allowed, but with a frequency less than once / 3 weeks) * Use of antidepressant medication is allowed if kept at a constant level
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in depressive symptomatology from baseline to the post-training assessment and follow-up (BDI-II) | baseline, 2 weeks, 3 months | Assessed using the Beck Depression Inventory (BDI-II) |
| Change in depressive rumination from baseline to the post-training assessment and follow-up (RRS) | baseline, 2 weeks, 3 months | Assessed using the Ruminative Response Scale (RRS) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quality of Life (QLDS) | baseline, 3 months | Assessed using the Quality of Life in Depression Scale (QLDS) |
| Resilience (RS) | baseline, 3 months | Assessed using the Resilience Scale (RS) |
| Remission from depression (RDQ) | baseline, 3 months | Assessed using the Remission of Depression Questionnaire (RDQ) |
| Disability (WHODAS 2.0) | baseline, 3 months | Assessed using the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) |
| (mal-)Adaptive cognitive emotion regulation (CERQ) | baseline, 2 weeks, 3 months | Assessed using the Cognitive Emotion Regulation Questionnaire (CERQ) |
Other
| Measure | Time frame | Description |
|---|---|---|
| Behavioral measure for cognitive control ((non-adaptive) PASAT) | baseline, 2 weeks, 3 months | Assessed using the (non-adaptive) PASAT |
| Self-reported cognitive control (BRIEF-A) | baseline, 2 weeks, 3 months | Assessed using the Behaviour Rating Inventory of Executive Function Adult Version (BRIEF-A) |
Countries
Belgium
Outcome results
None listed