Assessment of the Force Frequency Relationship of the Myocardium After On-pump CABG Surgery

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02407574

Enrollment

Registered

2015-04-03

Start date

2015-05-31

Completion date

Unknown

Last updated

2015-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult Cardiac Surgery

Brief summary

The aim of the study is to determine whether increasing the heart rate by epicardial atrial pacing after surgery improves the contractile force of the myocardium. After complete weaning from CPB, several pressure-loops of the LV will be recorded at different levels of preload using transoesophageal echo, invasive blood pressure monitoring. The preload will be manipulated by adding fluid from the CPB reservoir or draining fluid into the CPB reservoir.

Interventions

DEVICEExternal Pacing Box

Atrial pacing using an external pacing box

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* CABG only surgery * Preopeartive LVEF ≥ 53 % * Use of epicardial pacing wires to assist CPB weaning

Exclusion criteria

* Contra-indication to TEE * AV block at the time of CPB weaning * Sinus rhythm less than 50 or more than 90 BPM after CPB weaning.

Design outcomes

Primary

Measure	Time frame
End-systolic elastane of the left ventricle.	30 minutes after CPB weaning

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026