Dyslipidemia
Conditions
Keywords
cholesterol efflux, dyslipidemia
Brief summary
In previous study the investigators found that CoQ10 can improve cholesterol efflux from macrophages in cell model, ApoE mice model and small-scale of healthy volunteers. In addition, CoQ10 has strong antioxidant activity and is an essential factor of mitochondria electron transport chain. So the investigators hypothesize that CoQ10 may have some health promotion effect on dyslipidemia, risk factor of atherosclerosis and other cardiovascular diseases. On this purpose, the investigators are going to recruit 150 dyslipidemia patients to supply CoQ10+vitamin E or CoQ10 alone or placebo in different doses for 24 weeks to explore the effects of CoQ10 on cholesterol efflux and lipid profiles on dyslipidemia.
Interventions
DIETARY_SUPPLEMENTcoenzyme Q10 vitamin E softgel
4 coenzyme Q10 and vitamin E softgels per day for 24 weeks. Keep normal lift style unchanged.
DIETARY_SUPPLEMENTcoenzyme Q10 softgel
4 coenzyme Q10 softgels per day for 24 weeks. Keep normal lift style unchanged.
DIETARY_SUPPLEMENTplacebo softgel
4 placebo softgels per day. Keep normal lift style unchanged.
Sponsors
Sun Yat-sen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* The subjects were considered to have dyslipidemia if they met 2 of the following 4 criteria: * fasting total cholesterol concentration\>200 mg/dL, * fasting triglyceride concentration\>150mg/dL, * fasting LDL-cholesterol concentrations\>100 mg/dL, or * fasting HDL-cholesterol concentrations\>40 mg/dL.
Exclusion criteria
* history of CVD or other severe chronic disease or use of any drugs known to affect lipid metabolism. * use any antioxidant such as Vitamin E, vitamin C,Phytochemicals and coenzyme Q10 within two months before trial. * pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effects of CoQ10 on lipid profile | 6 months | Tg, Tc, LDL, HDL, APOA1,APOB |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effects of CoQ10 on blood glucose and insulin | 6 mouth | reflect insulin sensibility |
| Effects of CoQ10 on oxidative stress and inflammation | 6 mouth | — |
Other
| Measure | Time frame | Description |
|---|---|---|
| Effects of CoQ10 on FGF21 | 6 month | reflect glucose and lipid metabolism |
| Effects of CoQ10 on cholesterol efflux from macrophages | 6 month | — |
Countries
China
Outcome results
None listed