Cardiomyopathy, Chronic Kidney Diseases, Coronary Artery Disease, Fibrosis, Heart Failure, Inflammation
Conditions
Keywords
T1 mapping, CMR, Outcome, multicenter
Brief summary
Myocardial fibrosis is the fundamental substrate for the development of heart failure. Cardiovascular magnetic resonance (CMR) allows non-invasive assessment of myocardial fibrosis based on late gadolinium enhancement (LGE) and T1 mapping. Patients: Prospective longitudinal observational multicenter study of consecutive patients with suspected or known non-ischemic cardiomyopathy. Imaging: Non-invasive measures of myocardial fibrosis: native T1, extracellular volume fraction (ECV) and LGE. Primary endpoints: all cause and cardiovascular mortality. Secondary endpoints: arrhythmic composite and HF composite endpoints.
Interventions
None listed
Sponsors
King's College London
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. adults \> 18 years of age 2. clinical indication for CMR 3. able to provide informed consent
Exclusion criteria
contraindications for cardiac magnetic resonance imaging due to MR unsafe devices or objects
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Survival | 1 year | number of deaths |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rate of Arrhythmia | 1 year | number of fatal or aborted sudden cardiac death events (including a documented appropriate shock from ICD) |
| Rate of HF events | 1 year | Number of HF death and unplanned HF hospitalization |
| Rate of deaths due to cardiovascular causes | 1 year | Number of composite of sudden cardiac death (SCD), death from HF, death from stroke or thromboembolic event |
Countries
Australia, Germany, United Kingdom
Outcome results
None listed