Alcohol Abuse
Conditions
Brief summary
Participants will undergo a single session of functional magnetic resonance imaging (fMRI)-based neurofeedback (approximately 1 hour). The investigators will assess their ability to regulate motivational networks of the brain during the exposure to alcohol cues and evaluate immediate effects on craving and cognitive bias for alcohol by administering a questionnaire and a Stroop task before and after the session.
Interventions
OTHERNeurofeedback
Sponsors
European Commission
Cardiff University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* History of alcohol use disorder or current alcohol consumption above 21 units (1 unit = 8g) of alcohol per week (male participants) or above 14 units of alcohol per week (female participants)
Exclusion criteria
* MRI safety
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neurofeedback success (brain activation difference during neurofeedback and baseline blocks) | 1 day | This measure will be based on the analysis of participants' fMRI (functional magnetic resonance imaging) data, reflecting brain activation, during exposure to alcohol cues. Neurofeedback success will be defined as significant difference between activation levels (expressed as beta weights of a linear regression model) during the regulation periods compared to baseline. The significance will be determined by a t-test. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Drinking Urges Questionnaire as a measure of alcohol craving | 1 day | Measure of alcohol craving |
| Alcohol Stroop task as a measure of cognitive bias | 1 day | Measure of cognitive bias |
Countries
United Kingdom
Outcome results
None listed