Reflective Testing for Early Diagnosis of Pituitary Dysfunction

The Use of Reflex Strategies and Reflective Testing in the Clinical Chemistry Laboratory for Early Detection of Pituitary Dysfunction in Patients From Primary Care.

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02406417

Enrollment

Registered

2015-04-02

Start date

2015-03-01

Completion date

2015-03-01

Last updated

2024-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pituitary Dysfunction

Brief summary

Early detection and management of pituitary dysfunction reduces the morbidity that ensues as a consequence of missed or delayed diagnosis of this condition, and which may result in life-threatening events and increased mortality. The investigators study will explore the use of reflex strategies within the laboratory in capturing suspicious pituitary function test results from Primary Care patients and following these up with appropriate reflective testing. Subsequently patients identified from these results to have a possible underlying piuitary dysfunction will have an alert sent to their family physician prompting referral to the Endocrine team for further investigation and management.

Interventions

DEVICEInvestigation for pituitary dysfunction by blood tests.

Blood tests for pituitary function (one or more of the following tests: cortisol, LH, FSH, TSH, FT4, testosterone, prolactin) will be added to samples from patients identified as being at high risk from their initial blood results.

DEVICEDynamic function tests and pituitary imaging

Patients identified as being highly likely to have a pituitary dysfunction from the results of the blood tests for pituitary function added, will be referred to the Endocrine team for further tests in the form of dynamic function tests and pituitary imaging.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

16 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients from Primary Care found to have one or more abnormal pituitary function test picked up by the laboratory information system in the Clinical Chemistry laboratory.

Exclusion criteria

* Patients with known pituitary dysfunction or on medication that may affect pituitary function tests.

Design outcomes

Primary

Measure	Time frame
Number of patients found to have biochemical evidence of possible pituitary dysfunction	One year

Secondary

Measure	Time frame
Number of patients from primary outcome found to have true pituitary dysfunction	6- 12 months

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026