Case-control Study
Conditions
Brief summary
Obesity is directly related to an increased risk of diabetes mellitus, hypertension, dyslipidemia, cardiovascular disease, and overall mortality. Weight loss is effective in decreasing these risks and to reduce disease severity. Bariatric surgery is an effective therapy for sustained weight loss and type 2 diabetes (T2D) remission in most of the morbidly obese patients. But there is also a significant number of individuals with an inappropriate response to bariatric surgery. Two recent retrospective studies assessed the role of genetic load as a predictor of this response, but the results are still unelucidated. The aim of this study is to assess whether a selection of genetic variants may allow us to identify individuals who will have a satisfactory response after bariatric surgery in terms of weight loss and T2D remission.
Detailed description
A retrospective case-control study of 100 women who underwent bariatric surgery (Roux-en-Y laparoscopic gastric bypass): 50 pacients who were diabetic before surgery: 15 cases with less than 40% of the excess weight loss (EWL) and 35 cases with more than 75% EWL, matched with 50 non diabetic controles: 15 patients with less than 40%EWL and 35 with more than 75%EWL after one year. All individuals were analyzed with a genetic score from Nutri inCode. The predictive ability was analyzed by discrimination (area under the ROC curve), sensitivity and specificity and a score was calculated.
Interventions
GENETICGenetic test
Analysis of the main genetic variants associated with obesity are evaluated, mainly those related to the regulation of appetite, energy expenditure, adipogenesis, diabetes, inflammation of adipose tissue and others .
Sponsors
Hospital Universitari Vall d'Hebron Research Institute
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* women who underwent a gastric bypass with a minimum of 1 year follow-up, * aged between 18 and 60 years, * stable weight in the previous 6 months, * have signed the informed consent.
Exclusion criteria
* male, * with mobility problems that constrain a marked inactivity, * with pathology that limits the practice of within normal limits (chronic obstructive pulmonary cardiac cerebral vascular-disease, illness, accident sequel, etc ), * undergoing different surgical techniques to gastric bypass, * with severe psychiatric disorders or eating disorder.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Predictive value of the genetic test in identifying individuals who will have a good response to bariatric surgery, in terms of weight loss. | 6 month | Predictive value of the genetic test in identifying individuals who will have a good response to bariatric surgery, in terms of weight loss. |
| Predictive value of the genetic test in identifying individuals who will have a good response to bariatric surgery, in terms of type 2 diabetes remission after the surgery. | 6 month | Predictive value of the genetic test in identifying individuals who will have a good response to bariatric surgery, in terms of type 2 diabetes remission. |
Countries
Spain
Outcome results
None listed