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Importance of Patient Selection for Treatment of Infected Total Knee Prosthesis

Does the Selection of Patients Helps Healing the Infection After Change in One Step of a Knee Replacement?

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT02405702
Enrollment
60
Registered
2015-04-01
Start date
2015-03-01
Completion date
2016-01-31
Last updated
2025-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Infection

Keywords

Infection, Knee, knee replacement

Brief summary

The infection of a total knee replacement often imposes changing implants. The change in two step is currently considered the gold standard. The change in one step is a much debated attitude: strictly contra-indicated for some professionals, but others agree to reserve these for favorable suspected cases selected. Several criteria have been proposed in the literature: age, condition, duration of infection, known bacterium responsible, not virulent and sensitive to antibiotics, no fistula, no significant bone destruction. But these criteria are poorly validated, standing over an experience of surgical teams rather than high-level scientific studies. Some authors have proposed to achieve change in one step systematically. The results of these cohorts on healing the infection does not seem very different from the changes in two steps. But it is most often single-center series, uncontrolled, with small numbers.

Interventions

OTHERrestrospective study

Sponsors

University Hospital, Strasbourg, France
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Patients over 18 years * Patient having surgery for the management of knee infection after change in one step of a knee replacement prothesis in the participating services between 2000 and 2010.

Exclusion criteria

* Patients under 18 years

Design outcomes

Primary

MeasureTime frameDescription
Recovery from the infection measured visuallyfor the duration of hospital stay, up to 1 yearshow that the selection process of patients used improve treatment outcomes of infection in total knee replacement

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026