CPAP for Infantile Pompe Disease

Efficacy of Continuous Positive Airway Pressure of Treatment of Hypernasality of Children With Infantile Pompe Disease

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02405624

Enrollment

Registered

2015-04-01

Start date

2014-06-30

Completion date

2016-06-30

Last updated

2015-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pompe Disease

Brief summary

Patients with infantile onset Pompe disease will be trained with continuous positive airway pressure to see if hypernasality can be improved.

Interventions

PROCEDUREcontinuous positive airway pressure

CPAP training for muscle strength

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

4 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

1. confirm as Pompe disease 2. Age 4 and can speak 2-words sentence by order 3. mild to severe hypernasality 4. have regular speech therapy for 8 weeks or longer

Exclusion criteria

(1）hearing loss （2）congenital pharyngeal or laryngeal structure anomalies including cleft palate （3）cerebral palsy （4）recent otitis media effusion （5）very severe hypernasality （6）use non-invasive ventilator

Design outcomes

Primary

Measure	Time frame	Description
decrease in hypernasality	6 months	score hypernasality degree and compare

Secondary

Measure	Time frame	Description
increase in speech intelligibility	6 months	score speech intelligibility degree and compare

Countries

Taiwan

Contacts

Primary ContactYin-Hsiu Chien

chienyh@ntu.edu.tw886223123456

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026