Identification of the Blood Microbiota in Patient Suffering From Myocardial Infraction

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02405468

Acronym

FLORINF

Enrollment

202

Registered

2015-04-01

Start date

2013-07-31

Completion date

2015-12-31

Last updated

2016-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Disease, Myocardial Infarction

Keywords

blood microbiota, coronary disease, myocardial infarction

Brief summary

The investigators want to compare blood microbiota profile between patients with documented coronary lesions and patients free of coronary disease.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

35 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Cases : patients who have had a myocardial infarction within one month to one year before the inclusion * Controls : patients without history of myocardial infarction, free of coronary disease in the view of one of the following tests performed within one year before the inclusion : Effort test Echocardiographic stress test Myocardial perfusion scintigraphy Coronarography with \>= 2 major cardiovascular risk factors: 1. Treated hypertension, 2. Treated dyslipidemia 3. Current smoking 4. Diabetes mellitus

Exclusion criteria

* Infectious disease within one week before the inclusion * Immunocompromised patients * Antibiotic treatment within one month before the inclusion * Chronic viral infection * Chronic inflammatory intestinal bowel disease * Renal failure (estimated glomerular filtration rate\< 50 ml/min//1.73 m2) * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
blood bacterial 16s rDNA bacterial gene concentration	12 months	compare blood bacterial 16s rDNA bacterial gene concentration

Secondary

Measure	Time frame	Description
blood microbiota profile	12 months	compare blood microbiota profile as assessed at all taxonomic levels of interest (genus, family, order, class, phylum)

Other

Measure	Time frame	Description
microARN profile	12 months	Search a microARN profile corresponding to the coronary heart disease
lipid profile	12 months	Obtain an accurate lipid profile with a new technic of microelectrophoresis(Lipoprint)
modifications of the blood microbiota	12 months	Analyse modification of the blood microbiota in the case and the control
Serum Bank and DNA Bank	10 years	Form a Serum Bank and a DNA Bank for potential future analysis guided by microARN research
functional HDL	12 months	Analyse the functional qualities of the HDL from the serum

Countries

France

Outcome results