Hepatitis, Alcoholic
Conditions
Brief summary
ADDUP is an observational study of patients with alcoholic hepatitis. A structured interview is used to quantitatively estimate: 1. Alcohol use 2. Dietary intake 3. Drug use (legal and illegal) in the weeks preceding onset of acute alcoholic hepatitis. After interview patients are followed up for 12 months with regard to response to therapy and survival. The study is intended to explore potential precipitants of alcoholic hepatitis.
Interventions
OTHERInterview
Brief structured interview
Sponsors
University Hospital Birmingham
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* acute alcoholic hepatitis * aged over 18 years * able to give informed consent
Exclusion criteria
* evidence of other acute or chronic liver disease * episode of alcoholic hepatitis in 6 months before admission * severe hepatic encephalopathy * delirium
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in alcohol intake, dietary intake or drug use before illness | 1 month | Behavior before admission (Brief structured interview) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Survival after admission (Brief structured interview) | 12 months | Survival |
| Response to treatment (Brief structured interview) | 1 week | Response to treatment (corticosteroids, pentoxifylline or supportive medical care) after 1 week, measured by Lille score |
Countries
United Kingdom
Outcome results
None listed