Multiple Sclerosis, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Relapsing-Remitting
Conditions
Keywords
Multiple Sclerosis, MRI, rotating frame
Brief summary
The aim of this study is to develop novel magnetic resonance imaging (MRI) protocols suitable for patients with multiple sclerosis using advanced MRI such as rotating frame relaxation imaging. In addition, the investigators want to study the correlation between advanced MRI parameters and clinical disease progression.
Interventions
OTHERBrain MRI
Sponsors
Turku University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* The diagnosis of relapsing remitting MS made according to the Poser, McDonald's or revised McDonald's criteria (Group I) before participating in the study * Initial MS diagnosis of relapsing remitting form of the disease according to the criteria as mentioned above, and conversion into the secondary progressive phase of the disease as evaluated by the referring neurologist according to the clinical evaluation and confirmed by the study physician (Group II). * Mental status: Patients must be able to understand the meaning of the study * Informed consent: The patient must sign the appropriate Ethical Committee (EC) approved informed consent documents in the presence of the designated staff
Exclusion criteria
* Any other autoimmune disease than MS requiring immunomodulatory or immunosuppressive medication * High-dose corticosteroid treatment within 30 days before participating in the study * Prior medical history: Patient must have no history of serious cardiovascular, liver or kidney disease * Any psychiatric condition that compromises the subject's ability to participate in the study * Infections: Patient must not have an uncontrolled serious infection * No contraindications for MRI (cardiac pacemaker, intracranial clips etc)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MR relaxation values 0 | Baseline | Aim is to measure different quantitative MR relaxation values (e.g. Traff, T1rho) in different brain areas of patients with MS at baseline |
| MR relaxation values 1 | One year | Aim is to measure different quantitative MR relaxation values (e.g. Traff, T1rho) in different brain areas of patients with MS after one year follow-up |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MR relaxation values and clinical markers 0 | Baseline | Aim is to study the correlation between MR relaxation values and clinical markers of MS at baseline |
| MR relaxation values and clinical markers 1 | One year | Aim is to study the correlation between MR relaxation values and clinical markers of MS after one year follow up |
Countries
Finland
Outcome results
None listed