Healthy
Conditions
Keywords
Volunteers
Brief summary
The Centre for Magnetic Resonance in Biology and Medicine (CRMBM, UMR-CNRS 7339 AMU) obtained funding for a whole body NMR imaging at 7. It is the only MRI at 7T installed in a hospital in France (only two 7T MRI in France) and therefore a unique opportunity to develop new diagnostic approaches. The purpose of this study is to develop, implement and validate new MRI quantitative parameters derived from ultra high field MRI in order to characterize non-invasively with an unprecedented resolution and sensitivity, anatomy as well as certain physiological, hemodynamic and metabolic function of brain, spinal cord, musculoskeletal system, and heart in healthy subjects
Detailed description
The key is that the goal of our projects is not only producing images of better quality than using a 3T scanner but also making images differently, by highlighting new contrasts and features of theses organs in order to improve the diagnosis and prognosis of neurological, psychiatric, cardiovascular and rheumatologic diseases.
Interventions
PROCEDUREacquisition of normative database with ultra high field MRI
characterize non-invasively with an unprecedented resolution and sensitivity (high field MRI), anatomy as well as certain physiological, hemodynamic and metabolic function of brain, spinal cord, musculoskeletal system, and heart
DEVICEMRI
Sponsors
Assistance Publique Hopitaux De Marseille
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* People not presenting contraindications to the MRI (pacemaker, agitation, metallic brightness, claustrophobia etc.) * People having no intra-physical object potentially conductive. * People having no affection after detailed interrogation
Exclusion criteria
* People staying in a sanitary or social establishment * People in emergency situation * People not wishing to be informed about anomalies in the MRI * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| qualitative validation concerning structure visible with high field MRI | 4 years | the validation criteria are qualitative (contrast and visibility of anatomical structures usually visible 7T but not visible at 3T will be used to assess the sensitivity of images for each modality) and quantitative (signal to noise ratio (SNR), spatial and temporal resolution). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| acquisition of normative data and verification of the quality criteria obtained during the first phase | 4 years | During the second phase, we will acquire normative data and verify the quality criteria of the first phase. Each quantitative variable will be extracted. After the acquisition of the first 30 volunteers for each parameter, the variance will be analyzed to assess the population distribution. Depending on the results, and issues raised by clinical research studies, other populations will be acquired |
Countries
France
Contacts
Primary ContactMaxime GUYE, M.D
Backup ContactAlexandra GIULIANI
Outcome results
None listed