Infertility
Conditions
Keywords
corifollitropin alfa, recombinant FSH, HP-hMG, time-lapse, kinetics of development
Brief summary
The study is proposed to determine the effect of three types of gonadotropins that are currently used in protocols of controlled ovarian stimulation in women undergoing in vitro fertilization techniques on the kinetics of embryonic development.
Interventions
DRUGCorifollitropin alfa
Sponsors
IVI Madrid
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 37 Years
Healthy volunteers
Yes
Inclusion criteria
* Women \<38 years old * Weight \<60 kg * Own oocytes * Patients have to provide signed informed consent
Exclusion criteria
* Oocyte donors * Vitrified oocytes * Severe male factor (\<1 million spz/ml) * Weight \>60 kg
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| T5 defined as the time that embryo needs to reach a 5-cell stage. | Baseline |
Secondary
| Measure | Time frame |
|---|---|
| Total dose of gonadotropins (IU) | A month |
| Levels of FSH (IU) Levels of estradiol (pg / ml) - Levels of progesterone (ng / ml) - Fertilization rate - Number of embryos transferred and cryopreserved - Pregnancy rate - Implantation | A month |
| Levels of estradiol (pg / ml) Number of embryos transferred and cryopreserved - Pregnancy rate - Implantation | A month |
| Levels of progesterone (ng/ml) | A month |
| Fertilization rate | A month |
| Number of embryos transferred and cryopreserved | A month |
| Length of stimulation (days) | a month |
| Implantation rate | A monthe |
| Miscarriage rate | A month |
| Cancellation rate per cycle initiated | A month |
| Ovarian hyperstimulation syndrome rate | A month |
| Timings of cellular divisions | A month |
| Pregnancy rate | A month |
Outcome results
None listed