Brain Tumor, Glioma
Conditions
Keywords
muscle motor evoked potentials, spinal motor evoked potentials, D-wave, brain tumor surgery, intraoperative neuromonitoring
Brief summary
During neurosurgical resection of brain tumors within brain areas for motor control, it is important to monitor motor function. For this muscle motor evoked potentials are used. Those are elicited by transcranial and direct cortical stimulation. Motor responses are recorded from muscles. In neurosurgical procedures for spinal cord tumors, the same methods are used, but additionally motor activity is recorded from the spinal cord. This is called spinal motor evoked potentials. It is known that the relation between spinal and muscle motor evoked potentials helps to extent the resection of spinal cord tumors. This study implements the spinal motor evoked potential into brain tumor surgery and analyses the relationship between spinal and muscle motor evoked potentials. With this, detection of injury to the brain area for motor control might be discovered earlier and thus tumor resection can be performed safely.
Interventions
None listed
Sponsors
Johann Wolfgang Goethe University Hospital
Heinrich-Heine University, Duesseldorf
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \> 18 years * tumor location adjacent to the motor cortex and corticospinal tract
Exclusion criteria
* minor * neurological degenerative diseases * neurological immunological diseases * drug abuse * implanted medical devices such as cardiac pacemaker * spine deformation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| D-wave measurement | 24 hours | numeric assessment, amplitude and latency of D-wave |
| Clinical motor status according to the MRC scheme | 6 months | clinical motor status according to the MRC scheme |
Countries
Germany
Contacts
Primary ContactAndrea Szelenyi, MD PhD
Outcome results
None listed