Rheumatoid Arthritis
Conditions
Brief summary
ABSTRACT Introduction: Rheumatoid arthritis (RA) is a systemic inflammatory, chronic and progressive disease that can lead to joint destruction and important functional disability. Chronic inflammation, with a substantial increase in the amount of pro-inflammatory cytokines in synovial joint, is one of the biggest challenges in controlling RA. Resistance exercise has been recognized for positively modulate inflammation in healthy subjects. Objective: To evaluate the effect of an acute bout of resistance exercise on serum concentrations of tumor necrosis factor alpha (TNF-α), interleukin 1 receptor antagonist(IL-1ra), interleukin 1 beta (IL-1β), C reactive protein (CRP), interleukin 6 (IL-6), interleukin 10 (IL-10), and cartilage oligomeric matrix protein (COMP) in postmenopausal women with RA and women without the disease. Methods: 17 volunteers with RA and 17 without the disease, with a mean age of 54.7 + 6.63 underwent a resistance exercise session with a set of 12 repetitions at 50% of one repetition maximum (1RM ) and a set of 8 repetitions at 75% of 1RM. The exercises performed were: knee extension, knee flexion, hip abduction and hip adduction. Blood samples were obtained 30 minutes before, 5 minutes before, immediately after, 1 hour, 2 hours and 24 hours after the exercise session. Serum glucose concentrations prior to exercise were also measured. The investigators used the Student's't test, the model of analysis of variance with repeated measures and Bonferroni method of multiple comparisons to analyze the data, being considered statistically significant levels of p \<0.05.
Interventions
OTHERResistance training
17 volunteers with RA and 17 without the disease, with a mean age of 54.7 + 6.63 underwent a resistance exercise session with a set of 12 repetitions at 50% of one repetition maximum (1RM ) and a set of 8 repetitions at 75% of 1RM. The exercises performed were: knee extension, knee flexion, hip abduction and hip adduction. Blood samples were obtained 30 minutes before, 5 minutes before, immediately after, 1 hour, 2 hours and 24 hours after the exercise session.
Sponsors
Federal University of São Paulo
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
45 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
\*Rheumatoid Arthritis Group Inclusion Criteria: * Women classified acording to the American College of Rheumatology's criteria to rheumatoid arthritis * Post menopausal women * Stable medication three months before study
Exclusion criteria
* Women with rheumatoid arthritis with functional class IV, acording to ACR criteria * Women engaged in some type of regular exercise program; * Failure: heart, coronary, respiratory, renal and / or hepatic (uncompensated); * Uncompensated systemic hypertension; * Volunteers with other associated inflammatory diseases; * Unable to perform the exercises. * Control group We included in the control group of this study postmenopausal volunteers, without Rheumatoid Arthritis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in one (or more) of the inflammatory markers | 30 minutes before training; 5 minutes before training; 5 minutes after training; 1 hour after training; 2 hours after training; 24 hours after training | TNF-alfa, IL1-beta, IL1-ra, PCR, IL10, IL6 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| No change in inflammatory markers | 30 minutes before training; 5 minutes before training; 5 minutes after training; 1 hour after training; 2 hours after training; 24 hours after training | TNF-alfa, IL1-beta, IL1-ra, PCR, IL10, IL6 |
Countries
Brazil
Outcome results
None listed