Memory, Short-Term
Conditions
Brief summary
The aim of this study is to identify the effect of Polygoni Multiflori Radix complex extract on memory improvement using Rey-Kim scale for healthy people.
Interventions
DIETARY_SUPPLEMENTPolygoni Multiflori Radix complex extract
Intervention is manufactured by Chun-Ho food
DIETARY_SUPPLEMENTPlacebo
The placebo is filled with starch, so does not contain the active ingredient.
Sponsors
Korean Medicine Hospital of Pusan National University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* A person who is more than 50 years and lesser than 70 years of age * A person who's MQ(Memory Quotient) score is within more than 70 and lesser than 120
Exclusion criteria
* The patient who has past history related to memory * The patient who has Diabetes Mellitus * The person whose fasting blood sugar is more than 126mg/dL * The patients who has uncontrolled hypertension * The patient who has liver disorders * The patient whose AST(aspartate aminotransferase) or ALT(alanine aminotransferase) level is more than 60 IU/L(international units per liter) * The patients who has heart disorders (Angina pectoris, Myocardial infarction) * The patient who has past history related to excision of G-I tract excluding cecum * The patient who took drug or heal functional food within 4 weeks before screening * The patient who took decoction of herb within 4 weeks before screening * The patient who can't write or communicate * pregnant woman
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline on Memory Quotient score at 2 weeks and 4 weeks | baseline, at 2 weeks after taking experimental or placebo dietary supplement, at 4 weeks after taking supplement |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in Memory registration at 2 weeks and 4 weeks | baseline, at 2 weeks after taking experimental or placebo dietary supplement, at 4 weeks after taking supplement | Rey-Kim scale is a tool to assess the short-term memory. It is composed of AVLT and CFT. \# AVLT After tester speaks each 15 word, subjects are asked to tell all words immediately as memory serves. This process is repeated 5 times (Each process is called AVLT process 1-5 according to priority). After 20 minutes interval, subjects are also asked to tell all words they can remember (AVLT process 6). Right after that, subjects should select the words they heard among 35 words (AVLT process 7). Memory registration is calculated by converting score difference into a percentage between AVLT process 1 and 5 mentioned above. |
| Change from baseline in Memory retention at 2 weeks and 4 weeks | baseline, at 2 weeks after taking experimental or placebo dietary supplement, at 4 weeks after taking supplement | \# AVLT After tester speaks each 15 word, subjects are asked to tell all words immediately as memory serves. This process is repeated 5 times (Each process is called AVLT process 1-5 according to priority). After 20 minutes interval, subjects are also asked to tell all words they can remember (AVLT process 6). Right after that, subjects should select the words they heard among 35 words (AVLT process 7). Memory retention is calculated by converting score difference into a percentage between AVLT process 5 and 6 mentioned above. |
| Change from baseline in Retrieval efficiency at 2 weeks and 4 weeks | baseline, at 2 weeks after taking experimental or placebo dietary supplement, at 4 weeks after taking supplement | \# AVLT After tester speaks each 15 word, subjects are asked to tell all words immediately as memory serves. This process is repeated 5 times (Each process is called AVLT process 1-5 according to priority). After 20 minutes interval, subjects are also asked to tell all words they can remember (AVLT process 6). Right after that, subjects should select the words they heard among 35 words (AVLT process 7). Retrieval efficiency is calculated by converting score difference into a percentage between AVLT process 6 and 7 mentioned above. |
| Change from baseline in Copy-recall difference index at 2 weeks and 4 weeks | baseline, at 2 weeks after taking experimental or placebo dietary supplement, at 4 weeks after taking supplement | Rey-Kim scale is a tool to assess the short-term memory. It is composed of AVLT and CFT. \# CFT After tester shows subjects very complicated figure, subjects are asked to copy it (CFT process 1). Right after that, subjects should draw the figure as memory serves (CFT process 2). After 20 minutes interval, subjects are also asked to select the part of figure they copy among various figures (CFT process 3). Copy-recall difference index is calculated by converting score difference into a percentage between CFT process 1 and 2 mentioned above. |
Countries
South Korea
Outcome results
None listed