Sarcopenia
Conditions
Brief summary
This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of Ursolic Acid of Loquat Extract for treatment of muscle function improvement with relatively health adults. 54 subjects received 500 mg of Loquat Extract per day or a placebo for 12 weeks.
Detailed description
This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of Ursolic Acid of Loquat Extract for treatment of muscle function improvement with relatively health adults. 54 subjects received 500 mg of Loquat Extract per day or a placebo for 12 weeks. Change over time in muscle fuction was evaluated by four outcomes: assessment of appendicular skeletal mass using DEXA (dual energy X-ray absorptiometry); quadriceps muscle power by Biodex; hand grib power; and Short Physical Performance Battery, SPPB.
Interventions
DIETARY_SUPPLEMENTUA group
Ursolic Acid of Loquat Extract, 500mg/ day during 12 weeks
Sponsors
Pusan National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI 18.5-30KG/M2
Exclusion criteria
* \> SERUM creatinine 1.2mg/dL * \> AST or ALT 60IU/L * DM Patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| quadriceps muscle function | 12weeks |
Secondary
| Measure | Time frame |
|---|---|
| ASM(appendicular skeletal mass) marker | 12weeks |
| Short Physical Performance Battery, SPPB | 12weeks |
Outcome results
None listed