A Pilot Study of Ruxolitinib in Secondary Hemophagocytic Syndrome

Hemophagocytic Syndrome (HPS)

This is a pilot study to determine the efficacy of Ruxolitinib in secondary hemophagocytic syndrome. The primary objective is to assess the efficacy of ruxolitinib 15 mg PO twice daily in patients with HPS. The primary endpoint is overall survival at two months.

Hemophagocytic Syndrome (HPS) is a disorder characterized by pathological activation of the immune system resulting in a systemic disorder characterized by excessive cytokine production and macrophage activation, culminating in cytopenias and evidence of hemophagocytosis on tissue specimens. The disorder can be sporadic or familial due to one of several mutations and is primarily seen in the pediatric population, with a reported incidence of 1 case per 3000 admissions. The actual incidence in adults is unknown and can be rarely sporadic, or secondary to viral infections, malignancy, or autoimmune disease. HPS is a universally fatal disease if untreated. In adults, the median survival has been reported to be less than 2 months if diagnosis and treatment is delayed. Adult patients are treated with pediatric protocols with early institution of etoposide and steroids and consolidation with allogeneic stem cell transplant in appropriately selected patients if a familial form is identified. Other treatment strategies have been attempted, including rituximab, infliximab, entaracept, tocilizumab, and alemtuzumab. These anecdotal reports highlight the therapeutic potential of cytokine-targeted therapies in this disorder. This is a pilot study to determine the efficacy of Ruxolitinib in secondary hemophagocytic syndrome. The primary objective is to assess the efficacy of ruxolitinib 15 mg PO twice daily in patients with HPS. The primary endpoint is overall survival at two months. Patients will receive Ruxolitinib at 15 mg twice daily orally either on an empty stomach or with food for 4 weeks (28 days) in a 4 week (28 day) cycle. Ruxolitinib will be administered in continuous 28-day cycles. In the absence of treatment delays or cessation due to adverse events, treatment may continue indefinitely or until one of the following criteria applies: * Disease progression. * Intercurrent illness that prevents further administration of treatment. * The investigator considers it, for safety reasons, to be in the best interest of the patient. * Unacceptable adverse events such as any toxicity or other issue that causes a delay of study drug administration by more than 4 weeks. * General or specific changes in the patient's condition render the patient unacceptable for further treatment in the judgment of the investigator. * Patient decision to withdraw from treatment (partial consent) or from the study (full consent. * Death. Patients will be followed for toxicity for 30 days after treatment has been discontinued or until death, whichever occurs first.

United States

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