Colitis, Ulcerative, Crohn Disease, Intestinal Helminthiasis
Conditions
Brief summary
Mucosal immunology during helminth infection
Detailed description
The present study investigates the effects of Trichuris trichiura on human mucosal and systemic immunity in a single self-infected individual.
Interventions
BIOLOGICALTrichuris trichiura eggs
Live eggs from human whipworm, Trichuris trichiura
Sponsors
University of Aarhus
Study design
Observational model
CASE_ONLY
Eligibility
Sex/Gender
MALE
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* The included volunteer is a researcher within parasitology with main focus on Trichuris trichiura and Trichiura suis. He planned to infect himself and contacted our department with the purpose of being monitored during this infection for safety (medical supervision) and research reasons. The only clinical criterion for his inclusion in the study was that he was healthy.
Exclusion criteria
* N/A
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Faecal egg excretion | 30 weeks | Weekly monitoring of fecal egg counts by microscopy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mucosal T cell associated cytokines | Week 15 | Biopsy sampling during established infection |
| Systemic immune parameters (eosinophilia, Subtypes of circulating T cells) | 30 weeks | Weekly monitoring |
| Adverse events | 30 weeks | The included individual was monitored clinically every week for the development of diarrhea and weight loss, and by blood samples for anemia and inflammatory parameters every other week. |
Outcome results
None listed