Colon Cancer
Conditions
Keywords
Perioperative treatment, Laparoscopic surgery
Brief summary
An enhanced recovery program has been developed to provide for colon cancer patients faster and more personalized postoperative treatment. Most of the previous studies have showed that the efficacy of the enhanced recovery program on both subjective and objective physical recovery of patients. However, such studies are rarely conducted in South Korea. The purpose of this study is to evaluate the feasibility and efficacy of a postoperative enhanced recovery program in patients who underwent laparoscopic colon cancer surgery at a tertiary hospital in Korea.
Interventions
Enhanced recovery program day-1: no mechanical bowel preparation, intake permit until 6 hrs before operation day0: operation, postoperative fluid therapy, antibiotics day1: liquid diet, early ambulation, removal of foley catheterization day2-3: soft diet day 4-5: discharge
Sponsors
Kyungpook National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Eligibility rule of enrollment * ECOG 0-2 * Pathologically diagnosed colon cancer * Stage I-III * No functional disturbance in liver, kidney, bone marrow * Informed consent
Exclusion criteria
* Emergent operation * Obstructive or perforated cancer * Rectosigmoid or rectal cancer * Synchronous tumor * Uncontrolled psychiatric or neurologic problems * Severe hepatic dysfunction (GOT, GPT ≥100IU/L) * Renal dysfunction (Cr ≥2mg/dl) * Recent MI, CVA, nitrate medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Length of hospital stay | 30 days post-operatively | Duration of hospital stay from the date of operation to the date when a patient meets the following discharge criteria. Discharge criteria: * Tolerance of consecutive 3 soft diet * Recovery of bowel function (without PONV) * No necessity of intravenous analgesics * Stable vital sign (afebrile) |
| Actual hospital stay | 30 days post-operatively | — |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 30-day mortality | 30 days from time of surgery | — |
| Readmission rate | 30 days from time of surgery | — |
| Nutritional status | up to 30days from time of surgery | Body weight, body mass index, body composition, before and after surgery |
| Quality of life | up to 30days from time of surgery | EORTC QLQ-C30, before and after surgery |
| 30-day morbidity | 30 days from time of surgery | — |
Countries
South Korea
Outcome results
None listed