Computer-based Attention Training in Patients With Acquired Brain Injury

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02399293

Enrollment

Registered

2015-03-26

Start date

2013-04-30

Completion date

2014-09-30

Last updated

2015-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Injuries

Keywords

Cognitive training, Cognitive rehabilitation, Acquired brain injury, N-back, Visual Search, Cognitive transfer

Brief summary

Investigates computer based cognitive rehabilitation and training using the N-back task with a Visual Search task as an active control. The overall purpose is to provide (further) evidence about the efficacy (or lack of efficacy) of the N-back task and to find points of convergence and divergence between patients with acquired brain injury and non-impaired subjects.

Interventions

BEHAVIORALN-back

The N-back task required patients to monitor a continuous sequence of stimuli (in this experiment audio and visual stimuli). Press a button if the current stimulus is the same as that shown N back in the sequence. N increases if performance is good and decreases if performance is poor. Subjects train for 20 days, 12 blocks a day, 20+N trials per block. That is 240 blocks in total. A minimum of 10 blocks per day counts as a successfully trained day.

BEHAVIORALVisual Search

The Visual Search task consists of a NxN array of shapes. Press the button if a certain target stimulus is present in this array. N increases if performance is good and decreases if performance is poor. Subjects train for 20 days, 12 blocks a day, 20+N trials per block. That is 240 blocks in total. A minimum of 10 blocks per day counts as a successfully trained day.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* subjects should be able to do both task at level at the time of recruitment * Informed consent * (for brain injured patients) training must not interfere with treatment as usual. * (for brain injured patients) no symptoms which hinder testing and training. I.e. aphasia, deafness, tetraplegia etc.

Design outcomes

Primary

Measure	Time frame
Change from baseline Raven's advanced progressive matrices at the end of training	within five days after 20 full training days has been completed. Expected 3-6 weeks after baseline.

Secondary

Measure	Time frame
Change from baseline WAIS-III Working Memory Index at the end of training	within five days after 20 full training days has been completed. Expected 3-6 weeks after baseline.
Change from baseline WAIS-III Processing Speed Index at the end of training	within five days after 20 full training days has been completed. Expected 3-6 weeks after baseline.
Change from baseline Operation Span at the end of training	within five days after 20 full training days has been completed. Expected 3-6 weeks after baseline.
Change from baseline Stroop color-text interference at the end of training	within five days after 20 full training days has been completed. Expected 3-6 weeks after baseline.
Change from baseline AMPS at the end of training	within five days after 20 full training days has been completed. Expected 3-6 weeks after baseline.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026