Pancreatitis
Conditions
Brief summary
Endoscopic ultrasonography (EUS ) -guided fine needle aspiration (EUS -FNA ) of focal pancreatic lesions is an essential diagnostic procedure with high therapeutic effect in clinical routine. The aim of this study is to determine the levels of serum lipase, serum amylase and the tumor marker CA 19-9 prior and after EUS-FNA. In animal experiments on dogs, an increase of all three parameters was observed after surgery on the pancreas. For humans, these clinically important data are not yet available . It is assumed that the probability of pancreatitis with increased activity of lipase and amylase will rise with the number of puncture procedures as well as the size of the puncture needle. In addition, the post-interventional assessment of the tumor marker CA 19-9 could result in a false positive assumption of malignant neoplastic pancreatic lesion.
Interventions
PROCEDUREblood collection
blood will be taken for assessment of serum lipase, serum amylase and CA 19-9 prior to EUS-FNA
PROCEDUREfine needle aspiration
During endoscopic ultrasonography, fine needle aspiration will be performed for cytological analysis of the pancreas
Sponsors
Helios Albert-Schweitzer-Klinik Northeim
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* independent indication for pancreatic EUS-FNA * age ≥ 18 years * patient able to give informed consent
Exclusion criteria
* Contraindications for EUS-FNA * pregnancy * no informed consent available * known stenosis of esophagus or duodenum * relevant coagulation disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum lipase | up to 24h prior to EUS-FNA and 4 hours after EUS-FNA |
Secondary
| Measure | Time frame |
|---|---|
| CA 19-9 | up to 24 hours prior to EUS-FNA |
| Serum amylase | up to 24 hours prior to EUS-FNA |
Countries
Germany
Contacts
Primary ContactTobias Meister, PD Dr.
Outcome results
None listed