Hypertension, Prehypertension
Conditions
Brief summary
The specific aim of the proposed study is to address the efficacy of conventional full-fat dairy products as part of the normal routine diet for improving vascular function and reducing blood pressure in middle-aged and older adults with elevated blood pressure. The investigators hypothesize that dietary intervention including whole milk and full-fat milk products will induce significant decreases in systolic blood pressure and arterial stiffness. The investigators also test the hypothesis that the reductions in blood pressure will be associated with the corresponding decreases in arterial stiffness and/or increases in endothelial vasodilatory function as well as improvements in arterial baroreflex sensitivity. If our hypotheses are supported by the results, the information could be used as a basis for recommendations for the use of whole milk and full-fat milk products in the secondary prevention of elevated blood pressure and vascular dysfunction.
Interventions
DIETARY_SUPPLEMENTHigh fat dairy
Add 4 daily servings per day of high fat dairy (yogurt, milk, cheese) for a period of 4 weeks
DIETARY_SUPPLEMENTPlant-based
Add 4 daily servings of fruit (fruit cup, apple sauce) and/or plant-based milk, remove all dairy for a period for 4 weeks
Sponsors
Dairy Management Inc.
University of Texas at Austin
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Prehypertension or stage-1 hypertension
Exclusion criteria
* Consume \> 3 servings of dairy or fruit per day * Strenuous physical activity \> 3 time per week * Lactose intolerance, pregnancy, lactation, and/or alcohol abuse * Taking cardiovascular-acting drugs * Overt cardiovascular disease, metabolic disease, GI disorders and/or renal disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Seated blood pressure | 4 weeks |
Secondary
| Measure | Time frame |
|---|---|
| 24-hour ambulatory blood pressure | 4 weeks |
| Carotid arterial compliance as measured by arterial pressure and corresponding cross-sectional area by ultrasound | 4 weeks |
| Arterial stiffness as measured by pulse wave velocity between the aortic arch and femoral artery | 4 weeks |
| Flow mediated dilation | 4 weeks |
Countries
United States
Outcome results
None listed