Infertility
Conditions
Brief summary
To salvage the luteal phase and improve pregnancy rate in antagonist IVF/ICSI cycles triggered with GnRH agonist. Two strategies are compared supplementing the luteal phase with three small doses (500 IU) of HCG and giving a booster dose of HCG (1500 IU) on the day of ovum pickup.
Interventions
PROCEDUREIVF/ICSI
DRUGHuman Chorionic Gonadotropin
Given in different doses and timing to support the luteal phase
Sponsors
Nile Ivf Center, Cairo, Egypt
Adam International Hospital
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 37 Years
Healthy volunteers
No
Inclusion criteria
* High responder females undergoing antagonist protocol IVF/ICSI cycle * More than 14 MII oocytes * Estradiol more than 3500 pg/ml on day of trigger
Exclusion criteria
* Any other protocol * Normal or poor responders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical pregnancy rate | 1 year | The number of cycles with a positive pregnancy test and evidence of a gestational sac with fetal pulsations after 5weeks from pregnancy test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| OHSS rate | 1 year | The number of cycles with evidence of OHSS |
Other
| Measure | Time frame | Description |
|---|---|---|
| Chemical pregnancy rate | 1 year | The number of cycles with a positive pregnancy test after 14 days from embryo transfer |
| Early miscarriage rate | 1 year | Pregnancies that end up with miscarriage before 12 weeks gestation |
| Ongoing pregnancy rate | 1 year | Pregnancies ongoing beyond 12 weeks gestation |
| Live birth rate | 1 year | Pregnancies resulting in a live birth |
Countries
Egypt
Outcome results
None listed