Angiogenesis
Conditions
Keywords
Blood vessel, Fibroplasia, Wound healing, Insulin
Brief summary
Randomized, split plot, double-blind, placebo controlled trial. Half of the wounds surface was applied daily with insulin and the other half with saline solution as placebo. Biopsy specimens of the two sides were obtained on days 0 and 14. Number of blood vessels will be evaluated as main outcome.
Detailed description
Randomized, split plot, double-blind, placebo controlled trial. Non-diabetic patients with full-thickness wounds will be treated in the following manner: in half of the surface insulin will be applied in a daily basis, on the other half, saline solution will be used as placebo. Biopsy specimens of both sides will be obtained on days 0 and 14. Number of blood vessels will be evaluated as main outcome.
Interventions
DRUGInsulin
Half of the wound surface was treated daily with 10 units of intermediate insulin.
DRUGPlacebo
Half of the wound surface was treated daily with 0.1 cc of normal saline.
Sponsors
Universidad Autonoma de San Luis Potosí
Hospital Central Dr. Ignacio Morones Prieto
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Nondiabetic patients with full-thickness acute wounds
Exclusion criteria
* Diabetic patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of blood vessels | 14 days | In a biopsy taken at baseline, blood vessels will be counted |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hypoglycaemia | 14 days | Presence of capillary blood glucose of \<60 mg/dl |
Countries
Mexico
Outcome results
None listed