Helicobacter Infections
Conditions
Keywords
Sequential therapy, Triple therapy, Eradication
Brief summary
Clinical trial to compare efficacy on eradicating Helicobacter pylori with two antibiotic strategies: sequential with amoxicillin and omeprazole 5 days and clarithromycin with metronidazole and omeprazole 5 days or omeprazole with clarithromycin and amoxicillin 14 days.
Detailed description
In patients with documented infection with Helicobacter pylori after endoscopy and biopsy, two modalities of treatment were compared, and after a control endoscopy and biopsy, eradication was assessed as well as side effects of both treatments.
Interventions
Patient receive Omeprazole plus amoxicillin during 5 days and then omeprazole plus clarithromycin and metronidazole during another 5 days
DRUGTriple therapy
Patient receive Omeprazole plus amoxicillin and Clarithromycin during 14 days
Sponsors
Coordinación de Investigación en Salud, Mexico
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Helicobacter pylori infection in biopsy * Eradication required
Exclusion criteria
* Antibiotic received two weeks prior * Previous treatment for H pylori infection * Allergy to any of the treatment drugs * Smoking \> 5 cigarettes daily.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Eradication | 6 to 8 week after treatment | Helicobacter pylori in gastric biopsy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Side effects | two weeks after beginning of treatment | Nausea, vomiting, stomach ache |
Outcome results
None listed