Myocardial and Renal Dysfunction by Oxidative Stress Caused by Cardiac Surgery

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02394405

Enrollment

Registered

2015-03-20

Start date

2015-03-31

Completion date

2018-12-31

Last updated

2019-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Reperfusion Injury

Brief summary

Assessment of the severity of oxidative stress caused by the on-pump and off-pump cardiac surgery using mtDNA, nDNA, carbonilated proteins, nitrotyrosine, oxy-LDL, S100b-protein.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* shedduled CABG

Exclusion criteria

* stroke befor surgery * miocardial infarction 6 monthes befor surgery * dementia * liver cirrhosis

Design outcomes

Primary

Measure	Time frame
Assay of mtDNA	from baseline whithin 72 hours

Secondary

Measure	Time frame
Assay of nDNA	from baseline whithin 72 hours
Assay of carbonilated proteins	from baseline whithin 72 hours
Assay of nitrotyrosine	from baseline whithin 72 hours
Assay of oxy-LDL	from baseline whithin 72 hours
Assay of S100b-protein	from baseline whithin 72 hours

Countries

Russia

Outcome results