Extremity Orthopedic Surgery
Conditions
Keywords
Cardiac Troponin, Perioperative Period, surgery
Brief summary
This study will determine the extent of high-sensitivity cardiac troponin (hs-cTn) release in patients without cardiac risk factors undergoing extremity orthopedic surgery. This study will provide important evidence on how to interpret postoperative cardiac troponin elevations.
Interventions
PROCEDUREExtremity orthopedic or trauma surgery
hip, leg, shoulder, arm
Sponsors
Washington University School of Medicine
Medical University of Vienna
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-35 years * Extremity orthopedic or trauma surgery: leg, hip, arm, shoulder. * Planned overnight hospital admission * No cardiac risk factors (Lee's Revised Cardiac Risk Index Class 1) * American Society of Anesthesiologists (ASA) physical status I-II
Exclusion criteria
* Any history or symptoms of cardiac disease * Kidney or liver disease * Recent or current trauma to the trunk or head * Persons with increased vulnerability (e.g. cognitive limitations, prisoners,…) * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Perioperative change of high-sensitivity cardiac troponin plasma level | 24 hours preoperatively to postoperative day (POD) 1 | 3 samples: 1. Preoperative, 2. POD 0, and 3. POD 1 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Peak high-sensitivity cardiac troponin plasma level | 24 hours preoperatively to POD 1 | 3 samples: 1. Preoperative, 2. POD 0, and 3. POD 1 |
| Incidence rate of high-sensitivity cardiac troponin plasma level elevation | 24 hours preoperatively to POD 1 | 3 samples: 1. Preoperative, 2. POD 0, and 3. POD 1 |
Countries
Austria
Outcome results
None listed