Influenza, Severe Respiratory Infection
Conditions
Brief summary
Influenza is a major cause of morbidity and mortality. The investigators first goal is to evaluate soluble HLA-G5 isoform serum level as a potential marker of greater risk of death from Influenza respiratory illness in adult and pediatric patients hospitalized in reanimation. Secondly, the investigators collected respiratory samples in order to study the transcriptomic profiles of influenza-infected patients with severe symptoms.
Interventions
OTHERinfluenza cohort
Influenza is a major cause of morbidity and mortality. The investigators' first goal is to evaluate soluble HLA-G5 isoform serum level as a potential marker of greater risk of death from Influenza respiratory illness in adult and pediatric patients hospitalized in reanimation. Secondly, the investigators collected respiratory samples in order to study the transcriptomic profiles of influenza-infected patients with severe symptoms.
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Months to 99 Years
Healthy volunteers
No
Inclusion criteria
* Patient (Adult or Pediatric) * Hospitalized in reanimation * With a laboratory confirmed Influenza * That agree to take part in the study * Affiliated to National Health Insurance For ancillary group : * Adult at least 60 years old * Presenting at hospital for a blood test
Exclusion criteria
* non willing to participate * Influenza infection with no respiratory symptoms * pregnancy For ancillary group : * Presence of immunodepression defined by: * Cancer, or cancer cured for less than 2 years * Corticosteroids, Methotrexate (MTX), anti Tumor Necrosis Factor (TNF), anti-CD20 * Infection in progress (fever)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in ratio of the partial pressure of oxygen in arterial blood (PaO2) to the inspired oxygen fraction (FiO2), from admission at 7 days post-admission | The first, third, fifth and seventh day of hospitalization in reanimation | decreased arterial PaO2/FiO2 ratio ≤ 100 mmHg (≤ 13.3 kPa) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| All cause mortality | 90 days after hospitalization | — |
| Extracorporeal membrane oxygenation requirement | 90 days after hospitalization | — |
| SOFA score (Adult) PELOD (Pediatric) | The first, third, fifth and seventh day of hospitalization in reanimation | Elevated Score is considered as an evidence of clinical gravity |
Countries
France
Outcome results
None listed